Dermal & Cosmetic Research

Matrixyl

Palmitoyl pentapeptide-4

Also known as Palmitoyl pentapeptide-4, pal-KTTKS, Palmitoyl pentapeptide-3.

Palmitoyl pentapeptide-4 (pal-KTTKS), a lipidated fragment of the type I procollagen C-terminal propeptide studied in fibroblast collagen-synthesis assays.

Current lot: SN-MTX-2606
Purity: 98.94% by HPLC
Tested: Jun 25, 2026
Stocked in: United States, Canada, Australia

Synamino Sciences research vial with a silver cap on a teal background

Ships from

Vial size

$36.00

USD · 10 mg · In stock

Qty

Order by 2:00 PM PT for same-day dispatch from Reno, Nevada. 1–3 business days by USPS Priority and UPS. Free shipping over $150.00.

For laboratory research use only. Not for human or veterinary use.

About the compound

Matrixyl is a palmitoylated version of the pentapeptide Lys-Thr-Thr-Lys-Ser, a sequence taken from the C-terminal propeptide of type I collagen. The palmitoyl group increases lipophilicity, which is why it is favoured in formulation and skin-model research.

Supplied as a lyophilized powder. The compound is frequently studied alongside signal peptides such as argireline and SNAP-8.

Studied inCollagen synthesis · Fibroblast culture · Formulation science

Certificate of analysis

The certificate for the lot currently shipping. Every vial in that lot carries the same lot number on its label.

Certificate of analysis

Matrixyl · 10 mg

Lot SN-MTX-2606 · tested Jun 25, 2026

98.94%

Purity by HPLC

Labeled: 10 mg
Measured: 10.3 mg
Panel: 6 passed · 2 reported
Laboratory: Independent ISO/IEC 17025 accredited laboratory

Assay	Method	Result	Outcome
Appearance	Visual	White lyophilized powder	Pass
Purity	HPLC · spec ≥ 98%	98.94%	Pass
Net peptide content	HPLC	10.3 mg	Reported
Identity	LC-MS	Confirmed	Pass
Heavy metals	ICP-MS	Not detected	Pass
Sterility	USP <71>	No growth	Pass
Endotoxin	LAL · USP <85>	< 0.05 EU/mL	Reported
Residual solvents	GC-HS	Within limits	Pass

Specification and storage

CAS number: 214047-00-4
Molecular formula: C39H75N7O10
Molecular weight: 802.1 g/mol
Residues: 5
Sequence: Pal-KTTKS
Reference record: PubChem entry

Storage

Sealed lyophilized vials are stable at room temperature for short periods; store at 2–8 °C for routine use.
For long-term storage keep sealed vials at −20 °C, protected from light and moisture.
Reconstituted solutions should be refrigerated at 2–8 °C and used within the period defined by your laboratory's protocol.

Literature

Peer-reviewed publications on this compound. Provided for reference; they are not claims about this product.

01
International Journal of Cosmetic Science · 2005
Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin
Robinson LR, Fitzgerald NC, Doughty DG, et al.
02
Biomolecules & Therapeutics · 2014
Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS)
Choi YL, Park EJ, Kim E, et al.
03
Journal of Cosmetic Science · 2019
Effect of Palmitic Acid Conjugation on Physicochemical Properties of Peptide KTTKS: A Preformulation Study
Mortazavi SM, Kobarfard F, Maibach HI, et al.

Studied alongside

Argireline
Acetyl hexapeptide-8
from $30.00
SNAP-8
Acetyl octapeptide-3
from $32.00
GHK-Cu
Copper tripeptide
from $34.00

Research notice

Matrixyl is supplied for in vitro laboratory research and analytical use by qualified professionals. It is not a medicine, supplement or cosmetic, has not been evaluated by any regulator, and is not for human or veterinary use. Published findings cited on this page are provided for reference and are not claims about this product.