Cognitive & Sleep Research

Semax

ACTH(4–7) heptapeptide analogue

Also known as Met-Glu-His-Phe-Pro-Gly-Pro, ACTH(4–7)-PGP.

A synthetic heptapeptide built on the ACTH(4–7) fragment with a Pro-Gly-Pro C-terminal extension, studied in BDNF expression, neuroprotection and attention models.

Current lot: SN-SMX-2607
Purity: 99.58% by HPLC
Tested: Jul 23, 2026
Stocked in: United States, Canada, Australia

Synamino Sciences research vial with a silver cap on a slate-blue background

Ships from

Vial size

$36.00

USD · 10 mg · In stock

Qty

Order by 2:00 PM PT for same-day dispatch from Reno, Nevada. 1–3 business days by USPS Priority and UPS. Free shipping over $150.00.

For laboratory research use only. Not for human or veterinary use.

About the compound

Semax was developed as a stabilised analogue of the ACTH(4–10) fragment. Preclinical work examines its effects on neurotrophin expression and on outcomes in ischaemia models.

Supplied as a lyophilized powder.

Studied inNeurotrophin expression · Ischaemia models · Attention and memory models

Certificate of analysis

The certificate for the lot currently shipping. Every vial in that lot carries the same lot number on its label.

Certificate of analysis

Semax · 10 mg

Lot SN-SMX-2607 · tested Jul 23, 2026

99.58%

Purity by HPLC

Labeled: 10 mg
Measured: 10.2 mg
Panel: 6 passed · 2 reported
Laboratory: Independent ISO/IEC 17025 accredited laboratory

Assay	Method	Result	Outcome
Appearance	Visual	White lyophilized powder	Pass
Purity	HPLC · spec ≥ 98%	99.58%	Pass
Net peptide content	HPLC	10.2 mg	Reported
Identity	LC-MS	Confirmed	Pass
Heavy metals	ICP-MS	Not detected	Pass
Sterility	USP <71>	No growth	Pass
Endotoxin	LAL · USP <85>	< 0.05 EU/mL	Reported
Residual solvents	GC-HS	Within limits	Pass

Specification and storage

CAS number: 80714-61-0
Molecular formula: C37H51N9O10S
Molecular weight: 813.9 g/mol
Residues: 7
Sequence: MEHFPGP
Reference record: PubChem entry

Storage

Sealed lyophilized vials are stable at room temperature for short periods; store at 2–8 °C for routine use.
For long-term storage keep sealed vials at −20 °C, protected from light and moisture.
Reconstituted solutions should be refrigerated at 2–8 °C and used within the period defined by your laboratory's protocol.

Literature

Peer-reviewed publications on this compound. Provided for reference; they are not claims about this product.

01
Bulletin of Experimental Biology and Medicine · 2003
Effect of Semax peptide on survival of cultured rat pheochromocytoma cells during oxidative stress
Safarova ER, Shram SI, Zolotarev YA, et al.
02
Neuroscience and Behavioral Physiology · 2004
The neuroprotective effects of Semax in conditions of MPTP-induced lesions of the brain dopaminergic system
Levitskaya NG, Sebentsova EA, Andreeva LA, et al.
03
Cellular and Molecular Neurobiology · 2010
Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia
Dmitrieva VG, Povarova OV, Skvortsova VI, et al.

Studied alongside

Selank
Tuftsin analogue heptapeptide
from $36.00
DSIP
Delta sleep-inducing peptide
from $32.00

Research notice

Semax is supplied for in vitro laboratory research and analytical use by qualified professionals. It is not a medicine, supplement or cosmetic, has not been evaluated by any regulator, and is not for human or veterinary use. Published findings cited on this page are provided for reference and are not claims about this product.