Dermal & Cosmetic Research

Melanotan I

Afamelanotide · α-MSH analogue

Also known as Afamelanotide, [Nle4, D-Phe7]-α-MSH, MT-1.

A linear [Nle4, D-Phe7]-α-MSH analogue studied in melanogenesis and melanocortin-receptor research.

Current lot: SN-MT1-2607
Purity: 99.27% by HPLC
Tested: Jul 14, 2026
Stocked in: United States, Canada

Synamino Sciences research vial with a silver cap on a teal background

Ships from

Vial size

$35.00

USD · 10 mg · In stock

Qty

Order by 2:00 PM PT for same-day dispatch from Reno, Nevada. 1–3 business days by USPS Priority and UPS. Free shipping over $150.00.

For laboratory research use only. Not for human or veterinary use.

About the compound

Melanotan I is a synthetic analogue of alpha-melanocyte-stimulating hormone in which norleucine and D-phenylalanine substitutions extend its stability against enzymatic degradation. It is a standard tool compound in melanocortin-1 receptor and pigmentation research.

Supplied as a lyophilized powder for reconstitution.

Studied inMelanocortin receptors · Melanogenesis · Photoprotection models

Certificate of analysis

The certificate for the lot currently shipping. Every vial in that lot carries the same lot number on its label.

Certificate of analysis

Melanotan I · 10 mg

Lot SN-MT1-2607 · tested Jul 14, 2026

99.27%

Purity by HPLC

Labeled: 10 mg
Measured: 10.2 mg
Panel: 6 passed · 2 reported
Laboratory: Independent ISO/IEC 17025 accredited laboratory

Assay	Method	Result	Outcome
Appearance	Visual	White lyophilized powder	Pass
Purity	HPLC · spec ≥ 98%	99.27%	Pass
Net peptide content	HPLC	10.2 mg	Reported
Identity	LC-MS	Confirmed	Pass
Heavy metals	ICP-MS	Not detected	Pass
Sterility	USP <71>	No growth	Pass
Endotoxin	LAL · USP <85>	< 0.05 EU/mL	Reported
Residual solvents	GC-HS	Within limits	Pass

Specification and storage

CAS number: 75921-69-6
Molecular formula: C78H111N21O19
Molecular weight: 1646.8 g/mol
Residues: 13
Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Reference record: PubChem entry

Storage

Sealed lyophilized vials are stable at room temperature for short periods; store at 2–8 °C for routine use.
For long-term storage keep sealed vials at −20 °C, protected from light and moisture.
Reconstituted solutions should be refrigerated at 2–8 °C and used within the period defined by your laboratory's protocol.

Literature

Peer-reviewed publications on this compound. Provided for reference; they are not claims about this product.

01
Biopharmaceutics & Drug Disposition · 1997
Skin pigmentation and pharmacokinetics of melanotan-I in humans
Ugwu SO, Blanchard J, Dorr RT, et al.
02
Expert Review of Clinical Pharmacology · 2015
Afamelanotide (CUV1647) in dermal phototoxicity of erythropoietic protoporphyria
Minder EI, Schneider-Yin X
03
Pharmaceutical Biotechnology · 1998
Discovery and development of novel melanogenic drugs. Melanotan-I and -II
Hadley ME, Hruby VJ, Blanchard J, et al.

Studied alongside

Melanotan II
Cyclic α-MSH analogue
from $32.00
PT-141
Bremelanotide · MC4R agonist
from $34.00

Research notice

Melanotan I is supplied for in vitro laboratory research and analytical use by qualified professionals. It is not a medicine, supplement or cosmetic, has not been evaluated by any regulator, and is not for human or veterinary use. Published findings cited on this page are provided for reference and are not claims about this product.