Dermal & Cosmetic Research

Epithalon

Tetrapeptide AEDG

Also known as Epitalon, Epithalone, AEDG peptide.

The synthetic tetrapeptide Ala-Glu-Asp-Gly, modelled on the pineal extract epithalamin and studied in telomerase, cell-senescence and fibroblast-culture models.

Current lot: SN-EPI-2607
Purity: 99.52% by HPLC
Tested: Jul 28, 2026
Stocked in: United States, Canada, Australia

Synamino Sciences research vial with a silver cap on a teal background

Ships from

Vial size

$32.00

USD · 10 mg · In stock

Qty

Order by 2:00 PM PT for same-day dispatch from Reno, Nevada. 1–3 business days by USPS Priority and UPS. Free shipping over $150.00.

For laboratory research use only. Not for human or veterinary use.

About the compound

Epithalon (epitalon) was developed as a defined synthetic counterpart to the bovine pineal preparation epithalamin. Its short sequence makes it an accessible tool for studies of telomerase activity and replicative senescence in cultured cells.

Supplied as a lyophilized powder in two vial sizes.

Studied inTelomerase activity · Cell senescence · Pineal peptide biology

Certificate of analysis

The certificate for the lot currently shipping. Every vial in that lot carries the same lot number on its label.

Certificate of analysis

Epithalon · 10 mg

Lot SN-EPI-2607 · tested Jul 28, 2026

99.52%

Purity by HPLC

Labeled: 10 mg
Measured: 10.3 mg
Panel: 6 passed · 2 reported
Laboratory: Independent ISO/IEC 17025 accredited laboratory

Assay	Method	Result	Outcome
Appearance	Visual	White lyophilized powder	Pass
Purity	HPLC · spec ≥ 98%	99.52%	Pass
Net peptide content	HPLC	10.3 mg	Reported
Identity	LC-MS	Confirmed	Pass
Heavy metals	ICP-MS	Not detected	Pass
Sterility	USP <71>	No growth	Pass
Endotoxin	LAL · USP <85>	< 0.05 EU/mL	Reported
Residual solvents	GC-HS	Within limits	Pass

Specification and storage

CAS number: 307297-39-8
Molecular formula: C14H22N4O9
Molecular weight: 390.3 g/mol
Residues: 4
Sequence: AEDG
Reference record: PubChem entry

Storage

Sealed lyophilized vials are stable at room temperature for short periods; store at 2–8 °C for routine use.
For long-term storage keep sealed vials at −20 °C, protected from light and moisture.
Reconstituted solutions should be refrigerated at 2–8 °C and used within the period defined by your laboratory's protocol.

Literature

Peer-reviewed publications on this compound. Provided for reference; they are not claims about this product.

01
Bulletin of Experimental Biology and Medicine · 2003
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Khavinson VKh, Bondarev IE, Butyugov AA
02
International Journal of Cancer · 2002
Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
Anisimov VN, Khavinson VK, Provinciali M, et al.
03
Molecules · 2020
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
Khavinson V, Diomede F, Mironova E, et al.

Studied alongside

GHK-Cu
Copper tripeptide
from $34.00
NAD+
Nicotinamide adenine dinucleotide
from $52.00

Research notice

Epithalon is supplied for in vitro laboratory research and analytical use by qualified professionals. It is not a medicine, supplement or cosmetic, has not been evaluated by any regulator, and is not for human or veterinary use. Published findings cited on this page are provided for reference and are not claims about this product.